UnAuthorized Access issue

UnAuthorized Access issue

After I have created Web Cloud API based application,using App42 its app
key and secret for the JavaScript
sample(App42.initialize(appkey,appSecret)), but the console throw out:
{"app42Fault":{"httpErrorCode":401,"appErrorCode":1401,"message":"UnAuthorized
Access","details":"Client is not authorized"}}
Any idea?